Stand-up comedian Charlie Murphy died Wednesday after a bout with leukemia.
The older brother to actor Eddie Murphy was 57 years old.
According to TMZ, "Charlie died in a NYC hospital. His manager says he'd been going through chemo. He famously co-starred on "Chappelle Show" in some of Dave's most memorable skits ... including the night he partied with Prince."
Murphy was a successful comedian and actor with more than 50 credits to his name, according to his IMDB page.
Friend and comedic touring partner George Lopez posted a tribute to Murphy on Instagram.
"I'm heartbroken at the passing of our brother Charlie . In relationships you never want to leave anything unsaid , our conversations before shows and after shows we all told each other and Charlie how we felt ! Keep his family in your thoughts and in your prayers and keep a space for Charlie in you're heart," Lopez wrote.
Murphy was a regular on TV and co-wrote some of his brother's movies. He also appeared in the TV series "Are We There Yet?," "Black Jesus," "The Boondocks," and "Chappelle's Show," and he hosted his own comedy show, Charlie Murphy's Law, in 2014.
Murphy's film credits included "Night at the Museum," "Mo' Better Blues," "The Players Club," "Harlem Nights," and "Norbit," in which he voiced Floyd the Dog.
He recently toured with fellow comedians Cedric the Entertainer, Eddie Griffin, Lopez, and D.L. Hughley, and appeared in 50 Cent's hit TV drama Power, playing the role of Marshal Williams.
Murphy leaves behind two children from his marriage to late wife Tisha Taylor Murphy, who died in 2009.
The World Entertainment News Network contributed to this report.