Prisons spokeswoman JoEllen Smith said the powerful sedative pentobarbital will remain Ohio's primary method of administering the death penalty. A policy posted to the prisons department's website listed a combination of midazolam and hydromorphone as an alternative if sufficient pentobarbital isn't available or if the existing supply "is deemed unusable" by the medical team.
The agency's announcement came just days after its last supplies of pentobarbital expired. The last dose before the expiration was used to put condemned killer Harry Mitts to death Sept. 15 for shooting two people, including a suburban Cleveland police officer.
The alternative drug regimen was included in a revised overall capital punishment policy released by the state.
A federal judge had already indicated he'll review the new execution process. If he allows the state to go ahead, the compounded form of the drug will be used in the November execution of Ronald Phillips, sentenced to die for raping and killing his girlfriend's 3-year-old daughter in Akron in 1993.
The original manufacturer of pentobarbital, Denmark-based Lundbeck Inc., said in 2011 that it was putting the drug off-limits for executions. It required that prohibition remain when it sold the product to Lake Forest, Ill.-based Akorn Inc.
As a result, supplies had dried up in Ohio and around the country.
Friday's announcement is the third time the state has made a change related to the drug it uses in lethal injection.
In 2009, Ohio switched to a single dose of sodium thiopental. In 2011, it switched to pentobarbital when the manufacturer of sodium thiopental also restricted its distribution.
Among other states struggling to find alternatives are Georgia, Missouri and Arkansas. A legal challenge has placed Missouri's proposal to use propofol on hold, and anesthesiologists are asking the state to reconsider out of fear it could lead to restrictions of the drug needed for hospital use.
Arkansas' governor has held off scheduling executions as the state's Department of Correction plans to rewrite its lethal injection procedure to include a different drug or drugs and as prisoners continue to challenge the state's new execution law in court.
In Georgia, after the state's supply of pentobarbital expired in March, it acquired the drug from a compounding pharmacy. A lawsuit is challenging the state's decision to shield the pharmacy and contends the drug could be unsafe.
Ohio also has a backup method involving two drugs injected into muscles. That method has never been used.