The book, released April 30, describes the shocking details of Knox's experiences during her arrest, trial, imprisonment and eventual acquittal over the murder of her British roommate, Meredith Kercher.
The best-seller list ranks Knox's book as No. 5, based on its sales during the week ending May 12.
Inside the hundreds of pages of the memoir are claims by Knox that she was sexually harassed by prison guard Raffaele Argiro, saying he would summon her for "chit chats" alone in his office at night.
In the book, Knox reportedly expands on letters she wrote to friends saying the guard was fixated on the topic of sex, asking her about partners and if she would have sex with him. Argiro has denied the allegations.
Knox also reportedly writes about a female inmate who wanted to start a lesbian affair, about how she was falsely told by officials that she was HIV positive, and about her reaction to the hate campaign that followed her release, when prosecutor's in Italy called her a "she devil" and a "witch."
HarperCollins is publishing Knox's book, a deal reportedly worth $4 million. Knox talked with ABC News anchor Diane Sawyer in a prime-time special on April 30 to promote her book.
In March, Italy's highest criminal court overturned Knox's acquittal for Kercher's 2007 murder and ordered a new trial for Knox, 25. Italian law cannot compel Knox to return for the new legal proceeding.
Italian prosecutors have said Knox, who was an exchange student studying in Perugia, Italy, and her then-boyfriend Raffaele Sollecito killed Kercher in a drug-fueled sex assault involving a third man.
Prosecutors maintained that the murder weapon was a large knife taken from Sollecito's house. Prosecutors said the knife matched the wounds on Kercher's body and had traces of Kercher's DNA on the blade and Knox's DNA on the handle.
However, Knox's defenders said she was innocent and was forced to say things she didn't mean during a lengthy police interrogation. And they said bumbling Italian police contaminated the crime scene, producing flawed DNA evidence.
An Ivorian man is serving a 16-year sentence for Kercher's slaying. A new trial also has been ordered for Sollecito.