Two other passengers were hurt in the crash.
The crash happened at around 3 p.m. when Janice Smith, of Warm Springs, was driving east on the McKenzie River Highway with a woman and four children inside her car.
State Police Lieutenant Steve Mitchell said Smith veered onto the road's shoulder, over-corrected the wheel, crossed into oncoming traffic and crashed into a rock embankment near Vida.
Smith, her female passenger and one of the children were taken to Sacred Heart at Riverbend with serious injuries. Another child was flown to OHSU by air ambulance.
The two other children in the crash received some minor injuries, Lt. Mitchell said.
The crash caused long delays for drivers in the area, according to the Oregon Department of Transportation. | Traffic updates